The Relation-Ship Between Diabetes Mellitus And Some Blood Parameters And Liver Enzymes

: Objectives: The aim of present study was focused the light on the pathological changes in the some liver enzymes and triglycerides. Low Density Lipoprotein (LDL). High Density Lipoprotein (HDL), in the patients suffers from diabetes mellitus type 2. Methodology: The present study carried out on (21) patients effected with diabetes mellitus from (100) persons were examined in the education of Al-Sader hospital Al-Najaf in October, November and December 2012. The study include measurement of the glucose level, some of blood parameters, triglycerides, cholesterol, High Density Lipoprotein (HDL) and Low Density Lipoprotein (LDL), the biostatic use difference between the maximum and minimum values (range). Results: Our findings were revealed increase in the triglycerides in ten patients, the range of triglycerides are (205-398) mg/dl, and while the cholesterol level also increased in ten diabetic patients ( range 227-408 )mg/dl. So the GPT and GOT was elevated in seven diabetic patients ( range 48-59 ) I/U, but the low lipid density ( LDL ) was revealed decrease in the (18) males diabetic patients ( range 72-112) our observations were appeared some parameters of blood, the present study was noticed decrease the RBCs count in (13), diabetic females ( range 2.7-3.9 ) million corpuscles and increase in the blood platelets count in ten females diabetic patients ( range 410-520 )/cm 3 from blood. Conclusion: Increase in TG, cholesterol and GPT,GOT,LDL in diabetic patient, decrease in RBCs count and increase in Thrombocytes count in female diabetic patient. Recommendations: Further studies are needed to show the relation-ship between diabetes with endocrine disorder and immunological level


INTRODUCTION:
The type 2 diabetes mellitus was increased in the word and reached to endemic level in some countries such as india and china (1).Investigators (2) were approached to that the main complications, which accompanied the diabetes mellitus type 2, was liver diseases such as liver cirrhosis and led to high mortality when compared the diabetes mellitus with vesicular heart diseases, the researches were pointed out to the phenomena of insulin resistance, this play a rule as a central pathological changes in all the fatty liver disease ( non-alcoholic ) and the diabetes mellitus type 2 that consider as guide for diagnosis of liver metabolic disease syndrome (3).The type 2 diabetes mellitus was distinguished in similar symptoms in eachinsuline dependent and non-insulin dependent diabetes mellitus during the period of growth in the patients which represent the insulin resistance, that functional state which pointed to over growth and obesity (4), these may be led to diabetes mellitus type 2 occurrence, also the diabetes mellitus occurs in young patients, this disease is not isolate case from other pathological symptoms, but accompanied by abnormal metabolic processes which represents danger to cardiovascular system, these factors were collect in metabolic syndrome which represented by increase lipids in human body, obesity and hypertension (5,6).The aim of present study was focused the light on the pathological changes in the some liver enzymes and triglycerides.Low Density Lipoprotein (LDL).High Density Lipoprotein (HDL), in the patients suffer from type 2diabetes mellitus.

METHODOLOGY:
The present study was conducted on the (100) females and males patients age ranged (20-60) year were examined in October, November and December 2012in the education Al-Sader hospital in the Najaf provenance, twenty-one patients from (100) had increased in glucose levels in the blood, five milliliter of blood from each patients were taken from radial vein.Biochemical testes was including measurement of glucose level and blood parameters such ashemoglobulin level, Red blood cells corpuscles (RBCs) count, White blood cells count (WBCs), Erythrocyte sedimentation rate (E.S.R) and blood platelets count.Also the liver enzymes Glutamic pyruvate Transaminase (GPT) and Glutamic Oxalate transaminase (GOT) were measured as well as the Triglycerides, Cholesterol, High Density Lipoprotein (HDL) and Low Density Lipoprotein (LDL) were assessed, the biostatic use difference between the maximum and minimum values (range).

RESULTS:
Our findings was revealed, high number of male patients were affected by type 2 diabetes mellitus when compared with women patients, these results led to changes in some liver enzymes such as GPT and GOT, Triglycerides and Cholesterol, (Table 1).
The present study appeared decrease in Low Density Lipoprotein (LDL) level especially in male patients with type 2 diabetes mellitus, recorded decrease in RBCs count especially in females with type 2 diabetes mellitus.
Table1: Show the glucose level in blood, Triglycerides, Cholesterol and some liver enzymes in type 2 diabetic patients in the education Al-Sader hospital/ Najaf.Iraq.

Parameters
No In the table 1: increase in the glucose level in the (17) male, the (8) male diabetic patient revealed increase in the triglyceride but the cholesterol level also increase in male patient enzyme of the liver (GPT,GOT) elevated in the male patient when compare with the number of female.The LDL in the (18) diabetic male patient decrease in value when compare with normal.In the table 2: Decrease in RBCs count in the (13) female effected with the diabetic, the blood platelets count in (10) female with diabetes appeared increase value and the ESR in the ( 6) diabetic females revealed increase in the value.

DISCUSSION:
Our results were correspondence with previous studies (7) they mentioned, the (type 2) diabetes patients had cardiovascular disease, with high liver enzyme, and elevation in triglycerides and cholesterol, from other hand some investigators were pointed out, there are relationship between diabetes mellitus and thyroid diseases (8), they recorded elevation in thyroid stimulating hormone (TSH) in the type 2 diabetes patients.these results were agreedwith previous study (9) they reported there is association between the fatty liver disease and type 2 diabetic patients had abnormal value of liver enzymes besides affected by cardiovascular diseases.
These observations was varies with current studies (10), our observation about White Blood Cell count (WBCs) was revealed slightly increase in diabetic patients, that ensure the previous investigators (11), they suggested the (WBCs count) increasing in diabetic persons due to stimulation of bone marrow to produce neutrophils and eosinophil.
Our observations was identical with current study (12), they mentioned (E.S.R) increase belonged to bacterial and fungal infection which accompanied with diabetes mellitus.

CONCLUSIONS:
This present study was revealed increase in triglycerides level, cholesterol level, also elevation in GPT and GOT.And decrease in LDL in diabetic patients.
From another hand decrease in RBCs count in diabetic females and increase in blood platelets count.

RECOMMANDATIONS:
1-In the future, studying the association between diabetes mellitus and endocrine disorder.