Study on Neurotoxic effects of Digoxin different doses in mice

Abstract

The present study was designed to evaluate neurobehavioral effects of two  doses of  digoxin( therapeutic and double dose) in mice.Two treatment groups( T₁, T₂), each consist of 10 mice divided according to daily oral treatment with Digoxin representing dosing orally with 5 ,10microgram/kg  respectively the third group considered as  control and treated with distilled water.

Neurobehavioral results showed that digioxin in T2 caused significant decrease proportional with the dose in  autonomic and central  nervous system activity manifested by in decrease urination frequency and fecal boluses, disturbance  of vestibular system ,increase of time needed for 180° turning upward to avoid slope, and defect in degree of cognitive function of exploration , and neuromuscular compatibility with disturbance of  locomotor activity( proportional with dose and period of exposure) .

While T1 showed significant effect in disturbance  of vestibular system ,increase of time needed for 180° turning upward to avoid slope,and righting reflex  , and neuromuscular compatibility with disturbance of  locomotor activity( proportional with dose and period of exposure) ,while there were   no significant change in other parameters above at that period.

In conclusion  this study revealed that digoxin of both dose 5mcg/kg and10 mcg/kg in caused  abnormal neurobehaviord effect propotinal with the dose and period of expouser even at the therapeutic dose that indicate the precaution in using such drug.