Evaluation Of Some Biochemical Parameters In Patients With Breast Cancer In Basrah Governorate

Abstract

Breast cancer is the most frequently diagnosed life-threatening cancer in women and the leading cause of cancer death among women. Breast cancer is the second leading cause of cancer deaths among women . In  Iraq, breast  cancer  is  the  commonest  type  of  female  malignancy,  ac-counting for approximately one-third of the registered female cancers according to the  latest  Iraqi  Cancer  Registry.  In this study, patients and volunteers from Basrah Governorate (southern Iraq) participated. A total of fifty five participants were subdivided into two groups, breast cancer patients 35 aged (20-60) years, and 20 healthy individuals (control group) aged (20-60) years. Serum levels of Estrogen , Progesterone , glutathione peroxidase, superoxide dismutase , immunoglobulinG  , immunoglobulinM  and cancer antigen 15-3  were measured by standard methods. The study reported that Progesterone and IgG were statistically significant (p˂0.05) in patients with breast cancer compared to healthy control . Estrogen, glutathione peroxidase and superoxide dismutase  were statistically very high significant (p ≤0.0001) in patients with breast cancer compared to healthy control .There was very high significant positive correlation between estrogen and IgM  (p ≤0.0001) .