Preparation and characterization of chalcone compounds.

Abstract

The research includes Preparation of chalcones Preparation of chalcones in alkaline medium and reacting two types of ketones, Acetylnaphthalene-2 and 4-morpholino acetophenone, with four types of aldehydes, as eight types of new chalcones were prepared (H1, H4, H5, H6, H8) The compounds were identified by FT-IR, proton nuclear magnetic resonance spectra (¹HNMR) and electron aerosol ionization mass spectrometry (ESI), where this was confirmed by the compositions of the new chalcones prepared. The biological activity of the prepared compounds was studied for two types of pathogenic bacteria for humans, which are bacteria Gram-negative Escherichia coli, and Gram-positive bacteria Staphylococcus aureus that cause skin infections. Where the compound gave the highest efficacy compound H8 against both types of pathological bacteria under test, followed by compound H4 and then compound H6.