Estimation and Evaluation of The Antioxidant Enzymes Catalase,Glutathione-S-Transferees And lipid Patterns in Patients With Type 2 Diabetes in Basra Governorate – Iraq

Abstract

Type 2 diabetes occurs primarily as a result of two interconnected problems. Cells in the muscles, fat, and liver become resistant to insulin. Because the cells do not interact normally with insulin, they do not absorb a sufficient amount of sugar, and thus the pancreas becomes unable to secrete a sufficient amount of insulin to control blood sugar levels.  Since antioxidants have a role in treating diabetes by defending beta cells against oxidative stress, the current research was conducted to determine the levels of enzymatic antioxidants (Glutathione - S- Transferees (GST), Catalase (CAT)) and lipid profiles (cholesterol, lipids).  Triglycerides and lipoproteins (HDL, VLDL, LDL) in the blood serum of patients with type 2 diabetes compared to healthy people in Basra Governorate - Iraq, according to age. The number of patients in the study was (51) disease cases, including (19 males - 32 females) and (40)  In a healthy case (20 males - 20 females), it was found that there was a significant decrease at a significance level of P < 0.05 in the levels of (GST and CAT) in patients compared to healthy controls, and the decrease increases with age, while there was a significant increase at a significance level of (P < 0.01) in  Levels of (TG, TC, VLDL, LDL) in patients compared to healthy people with age, while high-density lipoprotein (HDL). The current study showed that there are no statistically significant differences in patients and with age.