Synthesis, Characterization and Enzyme activity of Cobalt Complex with New 2- Thioxoimidazolidine-4-one Ligand Derived from Schiff base

Abstract

In this work, a novel derivative of 2- thioxoimidazolidine-4-one (3-(((6-methoxynaphthalen-2-yl)methylene)amino)-2-thioxoimidazolidin-4-one) (L) has been synthesized by reacting 2-((6-methoxynaphthalen-2-yl)methylene)hydrazine-1-carbothioamide with ethylchloroacetate in the presence of sodium acetate, using 1,4-dioxane as the solvent. The chemical structures of the synthesized compound were determined using elemental analysis and a variety of physical and chemical techniques. Spectroscopic and magnetic moment studies were employed for this purpose. It was demonstrated that the metal complexes exhibited a geometric structure that exhibited an octahedral geometry. The synthesized complex was identified and their geometrical were suggested in solid state by using (FT-IR), (UV-Vis) spectroscopy, elemental analysis (C.H.N.S), flame atomic absorption technique, in addition to magnetic susceptibility and conductivity measurements. the inhibitory or activation effects of synthesized ligand and its metal complex on the activity of the alkaline phosphatase enzyme (ALP) at different concentrations.