Study The Role Of Functional Proteins In Sera Oh Iraqi Patients With Alzheimers Disease

Abstract

  The aim of the present study is to expose novel mechanisms and concepts regarding amyloid beta , albumin and hemoglobin in sera of Iraqi Alzheimer`s disease (AD) patients , and also to examine the biochemical action of memantine  on those parameters. . Sixty (60) diagnosed AD patients participated the present study and classified into four (4) groups: G₃ (52-78) was composed of (15) newly diagnosed males / without treatment , G₄    (64-90) years composed of (15) newly diagnosed females / without treatment , G₅ (60-85)  years composed of (15) males under treatment with memantine and G₆       (65-73) years composed of (15) females also under treatment with memantine. Memantine used as 10 mg /one dose daily. Patients were compared with healthy subjects as two control groups: G₁ composed of (15) males /(52-80) years and G₂ composed of (15) females / (64-82) years.. Results of the present study have revealed that Aβ level was significantly increased in sera of G₃ and G₄ compared with G₁ and G₂ respectively, while it was significantly decreased in sera of G₅ and G₆ compared with G₃ and G₄ respectively, non significant difference was reported between (G₅ and G₁) and between (G₄ and G₃) , however the difference between G₆ and G₂ was significant. Albumin level was highly significant increased in G₃ and G₄ compared with G₁ and G₂ respectively while it was highly significant decreased in G₅ and G₆ compared with G₃ and G₄ respectively, the difference between (G₅ and G₁),  (G₆ and G₂) and between (G₃ and G₄)was significant. Hemoglobin level was highly significant decreased in G₃ and G₄ compared with G₁ and G₂ respectively while it was significantly increased in G₅ compared with G₃ and highly significant in G₆ compared with G₄ , the difference between (G₅ and G₁) and between (G₆ and G₂) was non significant while it was highly significant between (G₃ and G₄). The present study submits unique and definite mechanisms regarding Aβ, hemoglobin and albumin (before and after treatment with memantine ) and exposes novel concepts to the clinical biochemistry in the term of the studied biochemical parameters. The present study also gives a hint to the difference between male and female AD patients regarding levels of the biochemical parameters before and after treatment.