Design, synthesis, molecular docking, and antibacterial assessment of a new ciprofloxacin metal-complex derivative
Keywords:
Fluoroquinolone, Azo linkage, Metal ionsAbstract
New azo containing and azo metal complex derivatives of ciprofloxacin ( D and E) were synthesized to increase its antibacterial activity and decrease microbial resistance caused by different bacterial species. Many types of metal ions can be used, in our research we used Ag+ . Some of the physicochemical characterstics and FT-IR were used to confirm the chemical structure of the resulting compounds. In silico study was done by using a molecular operating environment program (MOE) and it was noticed that the synthesized compounds showed a high affinity to the target site in topoisomerase enzyme. These results were compatible with invitro biological study.
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Kufa Journal of Pharmaceutical Sciences
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