Therapeutic Effect of Curcumin on Dermatitis Induced by Acetone in Female Rats

Abstract

The aim of this study was to evaluate different concertation of curcumin on induced atopic dermatitis in female Albino rats, particularly, immunomodulatory effect of curcumin in induced dermatitis by pure acetone 99.9% in female rats. Thirty rats were divided into two groups, control negative group (contain 6 female rats), control positive group (contain 24 female rats) include, dermatitis treated with curcumin 3% group, dermatitis treated with curcumin 5% group, dermatitis treated with pure gel group, the histopathological results of atopic dermatitis treatment by curcumin 5%, showed re-epithelialization activity maintained the epidermis layer, which showed normal thickness. Also, no inflammatory cells were observed in examined skin section. However, sloughing epithelial cells debris was observed above epidermis layer, the curcumin 5% group has a better healing effect comparison with curcumin 3%, determination of Interleukin 13. the study showed a significant increase in the control (+), At the curcumin gel 5% group of the experiment the result showed significant decrease (P<0.05) Interleukin 13 level than untreated group (+), pure gel group and there were decrease in other treated groups when compared to the untreated but slight. In atopic dermatitis the curcumin 5% gives best result in comparison with control positive groups because of it gives better therapy results. This study concluded that 5% curcumin effectively treats rat dermatitis, exhibiting superior therapeutic effects within 10 days, with IL-13 serving as a potential efficacy marker, while demonstrating safety and reducing complication risk.