Therapeutic Role of Trigonella Foenum- graecum L. Seeds Alone orCombined with Glimepiride in Mitigating Alloxan-Induced Hepatopathy inDiabetic Male Rats.

Abstract

High blood sugar indicates diabetes. These problems result from insulin synthesis, action, or
both failing. Insulin insensitivity or beta cell malfunction may cause it. Ginger, garlic, and Fenugreek
are used to treat diabetes. Diabetes, obesity, and other diseases are treated with it in the study, diabetic
rats had considerable liver histology changes and combination therapy groups had mild changes.
Giving Fenugreek, insulin, and Glimepiride improved liver health in diabetic rats, and using them
together had a good impact on liver function. Fifty male Wistar rats were divided into five groups
and type 2 diabetes was induced by feeding a high-fat unsaturated diet followed by intraperitoneal
injection of Alloxan (80 mg/kg) B.W. After one month of feeding on a high-fat diet induced diabetes
mellitus (DM). The aim of this study to examine the effect of water extracted of Trigonella Foeneum
graecum L. seeds on glucose metabolism and liver function in diabetic rats. Results indicated that the
oral administration of water extracted of Trigonella Foeneum graecum L. seeds not only improved
insulin sensitivity but also contributed to the overall restoration of liver health in the affected subjects.
Seeds in the reduction of blood glucose and the reduction of the pathological effect on liver and body
weight as an experimental animal model. In conclusion, the current study shows increase in the body
weight of rats during feeding on high fat diet for one month except group one which feeding on
normal diet. To induced type 2 diabetes and we notice the rat's weight loss and high blood sugar over
the last three weeks after injection intraperitoneal of rats by Alloxan to induced the DM. some
potential benefits of Fenugreek use. Oral Fenugreek showed improvements in blood glucose and liver
functions (AST, ALP and ALT levels) were reduced following Fenugreek treatment. Despite a
significant decrease in Triglyceride levels, Fenugreek use did not significantly alter Cholesterol
levels. Higher doses and longer Fenugreek treatment duration are recommended for the optimum
protection of the liver.