Evaluation of anti-bacterial activity of Capparis spinosa (Al-Kabara ) and Aloe vera extracts against Isolates Bacterial Skin Wound Infections in -vitro and in-vivo

Abstract

The aims of study was to investigate the antimicrobial activity of the flower extract of Capparis spinosa, gel and leaf extract of Aloe vera were tested against isolated bacterial from skin infection Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Pseudomonas aeruginosa and Escherichia coli. Part I, evaluation is done in-vitro by using hole plate method for appearance zone of inhibition. Antimicrobial susceptibility test showed that the C. spinosa was 100% effective against gram positive isolates and 90% activity against gram negative isolates, A. vera leaf was 20% effective against the entire tested gram positive as well as 15% effective against gram-negative isolates. A. vera gel showed 100% activity against gram negative and 74.6% against all tested gram positive isolates. Also it was found that mixture containing of Aloe vera, C. spinosa showed prominent antibacterial activity against gram negative and positive. Part II, evaluation is done in-vivo by study the effectiveness of flower extract of C. spinosa and gel of Aloe vera on the treatment of skin wounds inflamed by S. aureus suspension in rabbit. And from result the mixture can be used in the treatment of sun burns, rashes, burns, purulent wounds and other skin infections.