Effect of Antituberculosis, (Rifampicin & Isoniazide) on Female Reproductive System Performance in Adult Rats

Abstract

    A study   was   made    of    the     effects   of    anti-tuberculosis agents (Rifampicin, Isoniazide) on female   reproductive performance, (30) Adult   female albino    rats were   used, While ( 12 ) were    treated     orally   with  Rifampicin ( 50 mg/kg  )   and    Isoniazide  ( 25 mg/kg )    for   60    days , and    reversibility   of     the    induced     effects    by    withdrawal    of    the   treatment     for   30    days   were    also investigated ,  as   well    as   6    rats  served   as control  , Results   reveled    that  absolute   and   relative     weight    of     uterus   and    spleen    are  significantly   non   changed    , while   absolute   and   relative     weight  of   the ovary     decreased  significantly ,    relative    liver   weight    increased    significantly    , while   Isoniazide    cause   significantly   increased   in  heart     weight  ,  compared to control group, The     withdrawal    of    Rifampicin and    Isoniazide     for    30    days   brought    about     on    complete     recovery   , Fertility     was    reduced    significantly      after      both     Rifampicin and    Isoniazide     administration    for   60   days   , Hence     the   effects     of    Rifampicin and    Isoniazide are transient and reversible.