Assessment of Nephroprotective role of Irbesartan against gentamicin induced nephrotoxicity in rats

Abstract

Aims of study : The present study was undertaken to assess the renoprotective effect of irbesartan on gentamicin induced nephrotoxicity in male rats.

    Materials and methods: Fifteen male adult Sprague-Dawely rats were enrolled in this study, rats were separated randomly into 3 groups, five rats in each group, the first group  maintained on normal standard chow diet, served as control group. The second group  received gentamicin 100 mg/kg/day, i.p for 4 weeks. The third group received gentamicin 100mg/kg/day i.p concomitantly with irbesartan 25 mg/kg/day p.o for 4 weeks.

    Results: Gentamicin treatment increased serum urea, creatinine and tissue malondialdehyde (MDA) significantly. Irbesartan treatment decreased serum urea, creatinine and tissue MDA significantly.

    Conclusion: Gentamicin induced nenephrotoxicity can be prevented by coadministration with irbesartan.