Effect of Use Two General Anesthetic Regimes on Some Clinical and Biochemical Parameters in Donkeys

Abstract

    The present study was assigned to investigate  the effect of use two general anesthetic regimes (Tramadol, Ketamine and Xylazine ) and (Diazepam, Ketamine and Xylazine) on some clinical and biochemical parameters in donkeys. Eight  adult local breed donkeys weighting between (90- 160 kg) were used in this study. Donkeys were divided equally into two groups  (T+K+X)and (D+K+X) .

    Group(T+K+X): Four donkeys used to induction of general anesthesia by intravenous administration of the following drugs: Tramadol hydrochloride (5mg /Kg B.W.), Ketamine (2.2 mg/kg B.W) and Xylazine  (1.1 mg/kg B.W). Group (D+K+X): Four donkeys used to induction of general anesthesia was made by administration of the same drugs in the same dose as in group (T+K+X) except Tramadol that was replaced by Diazepam( 0.11 mg/kg B.W).

    Data were collected immediately before intravenous administration of premedication (control data) and continuously after administration of anesthetics. Parameters included clinical measures: heart rate and rectal temperature, at time of   5,10,15,20,25,30, and 60 minutes. The biochemical examination (AST and ALT) estimated at  the times zero, 25 minutes  and 3 days.

    The results revealed that significant differences in the means of heart rate  between groups (T+K+X)and(D+K+X) the heart rate was increase in (D+K+X)  group in compare with(T+K+X) group . as well as was significant differences in the  means of heart rate within(T+K+X) groups , it was  gradually increased at times 5 and 10 minute  then return close to control value at 15,20,25,30 and 60 minute while in (D+K+X) the means of heart rat were increased at all times in compared with zero time. There were significant differences in rectal body temperature between two groups , the means of rectal temperature were significantly increased in (D+K+X) group at 10,15 and 60 minutes . In addition there were gradual decreases in the rectal temperature within group at time 10, 15, 20, 25, 30 and 60 minutes in(T+K+X) while it was increased at 20 and 25 then stayed  within normal values in other group. There were no significant differences in the mean values of  AST between two  groups. AST mean was elevated significantly at Day 3 in (T+K+X)  but it was decreased at  time 25 minutes in(D+K+X).    The results also showed significant increase in ALT value  in (T+K+X) group in compare with (D+K+X) group at time 25 minutes but it was completely inversed at Day 3. At time 25 minutes ALT was increased significantly in (T+K+X) then decreased at Day 3 while it was decreased at times 25 minutes and Day 3 in (D+K+X).