The protective role of onion oil (Allium cepa L.)extract on some physiological parameters on Streptozotocin induced diabetes in male mice

Abstract

This study was carried out to investigate the most effective compound Extracted from approved selected anti diabetic plants on blood glucose, Serum insulin, lipid profile level and protective effect against oxidative stress  in Streptozotoci induced diabetic male mice. 30 albino male mice were divided into 3 groups 10 mice each one. Group 1 normal control, group2 diabetic control, Group3 received essential onion oil (50mg/kg B.w. orally),at the end of experiment Blood glucose, insulin levels, triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol were estimated. Oxidative stress biomarkers represented in the Amount of thiobarbituric acid reactive substances (TBARS) and nitric oxide were Determined. Liver and kidney removed for histopathological examination. the Results is isolated compound(onion oil) improved diabetes status but the most potent  was observed as anti diabetic& antioxidant effect.

    These results suggest that administration of the onion oil used as antidiabetic agent And improved diabetic status.