Analgesic activity of Trigonella foenium graceum (TFG) and Emblica officinalis (EO) extracts in white mice in comparison with diclofenac (Voltaren®)

Abstract

Present study aimed to explore the ability of  Trigonella foenium graceum (TFG) and Emblica officinalis  (EO) extracts  inducing the analgesic effect in comparison with diclofenac acid, Analgesic activity was assessed thermally as well as chemically induced pain by using hot plate test and formalin test. For hot plate experiment twenty albino mice were used of average weight 20g, randomly divided into four groups (5 each) and given TFG and EO extracts and diclofenac acid and mixture of TFG and EO orally at doses of 50mg/kg B.W, 250mg/kg B.W, 2mg/kg B.W and mixture of half doses of TFG and EO (25mg/kg B.W and 125mg/kg B.W respectively. TFG and EO extracts apart caused a significant increase in the reactive time to the thermal stimulus.For formalin experiment twenty five mice were used of average weight 20gm, randomly divided into five groups (5 each) and given TFG and EO extracts apart and mixture of half doses of both orally at same doses mentioned in hot plate experiment before the injection of 10 microliter ( μL) of 2% of formalin have showed a significant antinociceptive effect at the phases (early and late) and this may be attributed to their inhibitory effect on the nociceptive system and inflammatory mediators.