The Effect of Piracetam against Acetyl Choline (Ach) In Behavioral Changes with Some Biochemical Parameters in Adult Mice

Abstract

The effects of Piracetam against Acetyl Choline (Ach) in adult mice. The Medium Lethal Dose LD₅₀ of  Piracetam was 455.5mg/kg B.W. orally and Ach 7.25 mg/kg B.W i.p, then an animal’s are divided to 4 groups   First group serves as control group given normal saline, a second 400 mg /kg B.W. o.p. of Piracetam and third group 5 mg/kg B.W. i.p. Ach. Forth group 400 mg /kg B.W. o.p. of Piracetam and 5 mg/kg B.W. i.p. Ach. The behavioral changes, the Run time, swimming, Time on glass, and biochemical parameters in Ach and Piracetam pretreatment significantly (P<0.05) decreased of Run time and swimming, then increased Time on glass when compared with the control. The open field test was significantly (P<0.05) increased the termer, depression when compared with the control. The liver function tests was significantly (P<0.05) increased the in level of GPT and GOT enzymes in the plasma at forth group.