Analgesic and Anti- Inflammatory Effects of Hydro Alcoholic Extract of (Syzygium aromaticum) in Albino Mice

Abstract

The study was carried out to evaluate the analgesic and anti-inflammatory properties  of an  hydro alcoholic syzygium aromaticum extract (SAE) .The analgesic activity was measured by using the hot plate test with Twenty four (24)  mice divided randomly into four groups , T1, T2 received 100 , 200 mg /kg.bw of (SAE) while T3 dosed 50 mg /kg.bw of diclofanic acid and T4 used as control negative and dosed distilled water (D.W.) . The anti-inflammatory activity was measured by using formalin test with Twenty four (24)  mice divided randomly into four groups , T1and T2 dosed with 100 and 200 mg /kg.bw  respectively of (SAE)  while T3 group dosed 0.3 mg/kg.bw of meloxicam and T4 dosed  with (D.W.) ,  (all groups dosed orally before half hour of test)  and then calculate the time of analgesia and anti-inflammatory effects . The result showed  there is significant increase(p˂0.05)  in time of analgesia and significant decreases (p˂0.05)  in number of licking  in animal exposed to (SAE)  comparing with that of control ,  also there is significant increase(p˂0.05)  in time of analgesia and decrease in licking  in animals received diclofanic acid and meloxicam respectively  comparing with those received (SAE) and D.W the increase was dose dependent manner. In conclusion the hydro-alcoholic extract of clove E.C showed analgesic and anti-inflammatory effect