The effects of dapagliflozin on serum electrolytes concentration in adult male rats

Abstract

Hyperkalemia hazard is increased in diabetes, especially in patients with renal disease or those receiving angiotensin-converting enzyme (ACE) medications, angiotensin receptor blockers (ARBs) or potassium-sparing diuretics. Also, other diuretics can increase hypokalemia danger. Recently, We assessed  the effects of dapagliflozin in ameliorate the serum calcium, sodium, potassium( Ca⁺², Na⁺², K⁺ ) and uric acid concentration in  adults male  rats.  In this study were erolled 18  adult male rats  randomly  assigned to  three groups(n=6) as following: control group (I)  0.5 ml/kg B.W  of normal saline.

 Group II and III receive orally by gavage  for 30 days  0.53 mg/kg and 1.06 mg/kg B.W of dapagliflozin.  The end of experiment the blood were collected for measuring  the following parameter: blood glucose,  Ca⁺², Na⁺², K⁺ ) , and  uric acid concentration. The results of the present study revealed the following: there was significant  (P≤0.05) increase in body weight,  K⁺, Ca⁺² and uric acid concentration of  treated II, and III groups compared with control. On the other hand, there was significant  (P≤0.05) decrease in Na⁺²  concentration of treated compared with control.

 The experiment was  concluded that   Dapagliflozin in dose dependent pattern produce significant effects in reduction body weight in II and III groups compared with  I group, furthermore, shows that changes in serum concentrations  of potassium, calcium and uric acid in treated groups compared to normal where as no effects on sodium concentration was found. Also there is no differences in blood glucose concentration in treated group compared to normal, rather than hypoglycemic and all groups are normal groups.