Role of CoQ10 on Some Biochemical and Histological Aspects of Kidney in Rats Exposed to Sodium Fluoride

Abstract

This experiment was aimed to investigate the role of CoQ10 to alleviating the functional alterations of kidney - induced by sodium fluoride (NaF) in male rats. Twenty adult male Wister albino rats were randomly assigned into four  equal groups and treated for 42 days daily as follows: first group was received drinking tap water and intubated with DMSO 1% and serving as control (group C); second group ( group G1) received sodium fluoride 100ppm in drinking tap water ; third group (group G2) received sodium fluoride 100ppm in drinking tap water plus intubated 10 mg /Kg. B.W of CoQ10 orally , whereas fourth group ( group G3) intubated 10 mg /Kg. B.W of CoQ10 only. Fasting blood samples were collected at 0, 21, and 42 days of experimental periods. Then sera was isolated for estimated serum creatinine, blood urea nitrogen (BUN) and peroxynitrite radicals concentrations, as well as catalase activities has been measured. At the end of the experiment the animals were sacrificed and  sections from the kidney were taken for histopathological examination. The results revealed that rats received NaF (group G1)  for 42 days caused significant decrease in body weight and serum catalase activity , while a significant increase in the concentrations of serum creatinine, blood urea nitrogen (BUN) and peroxynitrite radicals accompanied with histopathological alterations of kidney were showed as compared to other experimental groups . On the other hand, administration of   CoQ10  to groups G2 showed an improvement of physiological and histological alterations and keeping the  kidney functions around the normal levels, manifested its protective effects against deleterious  effects of NaF. It could be concluded that  these results confirmed the antioxidant properties of CoQ10 against nephrotoxicity induced by NaF in adult rats.