Study the effects of Cadmium chloride on some cytogenetic parameters in albino rat

Abstract

The current study was carried out in the animal house of the Collegeof Medicinein Universityof Kufa. It was conducted also in  the laboratories of histopathology and biochemistry in Al-sadir Educational Hospital and Higher Education laboratory in the College of Education for girls / Kufa University, during the period 25/10/2008 – 19/3/2009. It was designed to demonstrate the influence of acute dose of Cadmium Chloride (75mg/kg) and oral subchronic administration (10,20,30) mg CdCl₂/L with drinking water for the periods (3,6,9) weeks in some cytogenetic parameter which include Argyrophilic Nucleolar Organizing Region (AgNOR) in duodenum, liver and kidney and the Micronuclei (MN) in Polychromatic Erythrocytes (PCE) of bone marrow.

    It is found that the effect of acute and subchronic administration in some of the cytogenetic parameters has reveal significant elevation in the mean of AgNOR of kidney and MN in PCE exposure to CdCl₂ in acute administration compared with the control group, while in subchronic administration the significant increase happened in AgNOR of kidney and liver tissues at the concentration 30 mg CdCl₂/L and period 9 weeks, in addition to significant elevation of MN which was affected by the elevation of dosing level (20,30) mg CdCl₂/L from drinking water, prolonged of duration ( 9 weeks ) and the  interaction between these two factors.