Preparation and evaluation a proniosomal gel for terbutaline sulfate as transdermal drug delivery system

Abstract

The rationale of the present study is to formulate and evaluate proniosomal formulations as transdermal carrier systems for terbutaline sulfate. Proniosomal formulations have been prepared from mixing of one or two types of  surfactants (span 20, span 40 ,span 60 span 80 ,tween 20 , tween 40 , tween 60  and tween 80 ),cholesterol and soya bean lecithin . Different formulas of terbutaline sulfate proniosomal preparations were prepared by changing the surfactant type. The microscopic observations showed that proniosomal gel formulations immediately converted to niosomal dispersions upon hydration. Their morphological properties have been determined by optical microscopy and scanning electron microscopy. The vesicle system was evaluated in-vitro for vesicle size, polydispersity, encapsulation efficiency of drug and permeation of terbutaline sulfate through excised rabbit skin. Optical microscope and scanning electron microscope pictures showed spherical shaped for all niosomes formulations of terbutaline sulfate and the size range in micrometer were 8.82-0.294, while the encapsulation efficiencies were 88.06%-39.46%. In addition better permeation was obtained from proniosomal gel through rabbit skin.