Study The Analgesic And Anti-Inflammatory Activity Of Zingiber Officinale Rhizome Extract Comparison With Ibuprofen In Male Mice

Abstract

The aim of the present study was to explore the probable analgesic and anti-inflammatory activity of  ethanolic extract of Zingiber officinale  by using Hot plate test , acetic acid – induced writhing and  Carrageenan induced inflammation in male mice. Thirty Albino male mice (average weight 20g) were used and randomly divided in this study (six animals were used in each groups test for Zingiber officinale  in doses of 100, 200 and 300 mg/kg B.W, Ibuprofen 20mg/kg B.W and control ( gave distilled water).The results were expressed as the Mean ±SEM and the statistical significance of differences between groups was analyzed by two Way Analysis of Variance (ANOVA) . The extract  showed a significant inhibition of  writhing response and increase in hot plate reaction time and also caused significant decrease P<0.05 in paw oedema that induced by Carrageenan comparable with Ibuprofen that standard drugs used. We can conclude from the outcome of the present work that Zingiber officinale extract exert an excellent analgesic and anti-inflammatory effect in the mice and exhibit peripheral and central analgesic effect and anti-inflammatory activity, which may be attributed to the various phytochemicals present in rhizomes of  Zingiber officinale  .