Study of in vitro and in vivo cytotoxicity effect of some medicinal plants

Abstract

The medicinal plants contain many ingredients which enhance the development and synthesis of many drugs the ingredients content of medicinal plants that have therapeutic activity naturally synthesized and accumulated in plants. The presence study was conducted to investigate in vitro and in vivo cytotoxicity effect of some medicinal plants, extracted by soxhlet with methanol alcohol and fractionation of active constituents from Curcuma longa L. rhizomes , Commiphora myrrha L. gums and Ginkgo biloba L. leaves with water , chloroform , ethyl acetate and hexane. The methanolic alcohol extract and fractions of Curcuma longa L. rhizomes , Commiphora myrrha L. gums and Ginkgo biloba L. leaves show ( in vitro ) relatively significant (p ≤ 0.05) low cytotoxicity against RBC , while ( in vivo ) the cytotoxicity at 2000 mg / ml did not occur which indicated the study plants safety.