Synthesis and characterization of new 1,3-thiazinane derivatives and study their effect on breast cancer (MCF-7)
Keywords:Chalcone, thiazinane derivatives, breast cancer, MCF-7
The research includes synthesized some thiazinane (hexahydrothiazine) derivatives were synthesized from the reaction of chalcons with thiourea. FT-IR, Mass, and H1-NMR spectra identified the compounds. The new thiazinane derivatives (SH, Sm-NH2, Sp-NH2, Sp-NO2) applied on breast cancer (MCF-7) gave a different results. The inhibition ratio of prepared compounds according to the type of the substituted group where the thiazinane derivative with an amino group on meta position (Sm-NH2) was (75%). The thiazinane derivative without a substituted group (S.H.) was (47% ), then with an amino group on para position (Sp-NH2) was (26%), and with a nitro group on para position (Sp-NO2) was (5%).
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