Synthesis, Characterization and Spectral Studies of Some Metal Ions Complexes with New Schiff Base Ligand Derived From 6- Amino Penicillanic Acid And Biological Screening Study For The Pt(II) Complex.
DOI:
https://doi.org/10.36329/jkcm/2023/v3.i1.11835Keywords:
6-amino pencillic acid, New Schiff base, Transition metal complexes, antitumor (colon cancer)Abstract
The complexes of Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg (II) and Pt(II)were prepared from the complexation reaction between the new Schiff base ligand and Selected Metal Ions. Ligand was derived from the condensation reaction of Oxo(4-(pyridin-2-yl)phenyl) methyline, 4-amino antipyrine, and 6-amino pencillic acid ). The ligand and its complexes were characterized by C.H.N elemental analysis, Uv-Vis, FT-IR, and molar conductivity, Atomic absorption, magnetic moment measurements and mass spectra studies. The results of this studies show the coordination sites for the ligand with the metal ion were to be through oxygen, nitrogen atoms of 6-amino pencillic acid, and the nitrogen atom of 4-amino antipyrine. The complexes were found to have the general formula [(M)(L)2]Cl2 where M = Co(II), Ni(II), Cu(II), Zn(II), Hg(II), and Cd(II), except the [Pt(L)Cl]Cl. The electronic spectral and magnetic measurement data indicated that the complexes exhibited octahedral geometry, except the Pt(II) complex suggested a square planar geometry around the central metal ion. The ligand forms shape as natural tridentate manner. The biological activity results showed the inhibitory effect for platinum(II) the complex. In this study the cytotoxicity of Pt(II) complex on human colon cancer cell line LS 174 T CRC was investigated and African green monkey kidney cells normal cells were MTT assay. The metal complexes showed selective cytotoxicity against colorectal, this metal Complex excelled in halting proliferation of LS 174 T CRC cancer cells line with median inhibitory concentration (IC50) values of Pt(II) complex. The results indicate undoubtedly the possibility of using them as antitumor drugs in the field of pharmacy colon cancer.
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