Anew Merging-Zone Flow Injection System For Determination Of Zn_(II) in Pharmaceutical_ Samples By New Reagent Derivative From 4- aminoantipyrine

Abstract

A straightforward, automatic, delicate fresh , high throughput sample and creative spectrophotometric design for a new Merging Zone Injection system The automated_  method_ is based on the formation of red complex_ between Zn_(II) and new reagent (4(4-(1,5 dimethyl-2-phenyl-pyrazole-3-one azo)-2-methoxy -5- propenyl- phenol)(DMPPAMPP) at 490 nm to measure Zn(II). The impact of several system factors, including flow rate, reaction coil, and others, was examined. length, sample volume, reagent volume, reagent concentration, and medium pH. The determined linearity range , detection's limit LOD and  limit of quantification was found to be

 1 to 10 mg ml⁻¹,0.323 mg_.L⁻¹, and 1. _076 mg.L⁻¹, correspondingly

, 120 samples per hour is the sampling frequency. The technique was successfully used to determine the amount of Zn(II) in pharmaceutical formulations. The recovery average ranged between 90.35and 118.45%.