Synthesis, Characterization of New Metal Complexes of Ligand [3-(4-hydroxyphenyl)-2-(3-(4-methoxybenzoyl) thio ureido)propanoicacid] (HMP ) and Study of the Biological Activity

Abstract

A new ligand [3-(4-hydroxyphenyl)-2-(3-(4-methoxybenzoyl)thioureido)propanoic acid]   (HMP) was synthesized by reaction of Tyrosine and, 4- methoxy benzoylisothiocyanate ,  and used for the synthesis of a series of new metalcomplexes  cobalt(II) Nickel (II), Copper (II), Zinc(II) , Palladium(II),  Cadmium (II), mercury (II). The mineral complexes were characterized by molar conductivity, elemental analyzes (C.H.N.S), and spectroscopic techniques: electronic spectral UV-Vis , infrared FT-IR , ¹H- NMR, ¹³C-NMR and magnetic properties . The results confirmed that the ligand (HMP) behaves as a Bidentate and coordinates with the metal ion via the oxygen atom of the carboxyl group and an nitrogen atom of the amine group. The antimicrobial properties of all newly synthesized compounds were also demonstrated against the bacterial pathogenic organisms Escherichia coli (G-) and Staphylococcus aurous (G+) by the agar-well diffusion technique. These complexes are more effective against bacteria compared to the Amoxicillin  antibiotic. The aim of this study describes the characterization and synthesis of the new ligand (HMP) derived from Tyrosine and its metal complexes with knowing their effect on selected bacteria.