Synthesis and Characterization of some new heterocyclic derivatives from terphthaldehyde and study of their biological activity
DOI:
https://doi.org/10.36329/jkcm/2023/v3.i1.12260Keywords:
Terphthaldehyde, Chalcones, thiazineAbstract
In this study, some new heterocyclic compounds have been synthesized including the preparation of some chalcone from the reaction terphthadehyde with two moles of ketone derivative p-hydroxy acetophenone in a basic medium, After that . The stage includes the preparation of new heterocyclic compounds five-membered ( pyrazole, Isoxazole) and six-membered ( oxazine, thiazine). The prepared compounds were characterized by FT-IR,1H-NMR, and 13C-NMR techniqes, in addition to their melting points and TLC (Thin Layer Chromatography).Finally,the prepared compounds are tested against Gram-positive and Gram-negative bacteria to study their biological activity.
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Copyright (c) 2023 Zainab Hassan Rahim, Nadia Sadiq Majeed
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