One-pot Multicomponent Synthesis and Biological Activity of Oxindole- linked Isatin Schiff Bases Derivatives

Abstract

The study focuses on the synthesis of  isatin- oxindole compounds through a two-step process. In the first step, using mannich reaction, new derivatives of Isatin are synthesized by reacting Isatin with either oxindole, along with formaldehyde. This reaction results in the formation of Isatin- oxindole derivative. In the second step, these Isatin derivatives are further reacted with various aniline derivatives to generate new compounds containing Isatin. The synthesized compounds are characterized using spectroscopic techniques such as FTIR, ¹H NMR, and ¹³C NMR. The study also explores the biological activity of some of the synthesized compounds against specific bacteria strains, such as Klebsiella pneumoniae and Staphylococcus aureus. These compounds are assessed for their potential antimicrobial properties.