Synthesis , Characterization and Study the Effect of Benzothiazol-pyrazole Derivatives on the Activity of AST, ALT Enzymes

Authors

  • Abbas A. Mohammed Mustansiriyah University, College of Science, Department of Chemistry, Baghdad, Iraq
  • Hamid H. Mohammed Mustansiriyah University, College of Science, Department of Chemistry, Baghdad, Iraq
  • Mustafa T Mustansiriyah University, College of Science, Department of Chemistry, Baghdad, Iraq
  • Zahraa abed hussain Mustansiriyah University, College of Science, Department of Chemistry, Baghdad, Iraq
  • Zainab N. Mageed Mustansiriyah University, College of Science, Department of Chemistry, Baghdad, Iraq

DOI:

https://doi.org/10.36329/jkcm/2022/v2.i9.13297

Keywords:

Benzothiazole, Pyrazole, Biological Activity

Abstract

  This work includes synthesis some of 2-(4,5-dihydro-1H-pyrazol-1-yl)-1,3-benzothiazole derivatives which synthesized from 2-hydrazino-1,3-benzothiazole with dicarbonyl compounds. The prepared compounds were characterized by FT-IR, 1HNMR and also studied the physical properties. The effect of the biological activity for these compounds were studied on the activity of AST and ALT enzymes in human serum of myocardial infarction patients. The studies show the compounds (A2 and A5) caused inhibition while the compound (A3 and A4) caused activation for the activity for  AST and ALT enzymes.

Downloads

Download data is not yet available.

Downloads

Published

2023-08-28

How to Cite

Abbas A. Mohammed, Hamid H. Mohammed, Mustafa T, Zahraa abed hussain, & Zainab N. Mageed. (2023). Synthesis , Characterization and Study the Effect of Benzothiazol-pyrazole Derivatives on the Activity of AST, ALT Enzymes. Journal of Kufa for Chemical Sciences, 2(9), 242–263. https://doi.org/10.36329/jkcm/2022/v2.i9.13297

Issue

Vol. 2 No. 9 (2022): Journal Of Kufa For Chemical Sciences

Section

Peer-reviewed Articles

License

Copyright (c) 2023 Journal of Kufa for Chemical Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Open-access Statement
The journal « Journal Of Kufa For Chemical Sciences» provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Full-text access to scientific articles of the journal is presented on the official website in the Archives section.

This is in accordance with the BOAI definition of open access. The licensing policy is compatible with the overwhelming majority of open access and archiving policies.

The journal «Journal Of Kufa For Chemical Sciences» is an open access journal, which means all its content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.The journal is licensed by Creative Commons Attribution International( CC Attribution 4.0) .

Similar Articles

1 2 3 4 5 6 7 > >> 

You may also start an advanced similarity search for this article.