Preparation, Characterization, and Study of Antibacterial some new Pyrazole Derivatives

Abstract

The papear include synthesis of four of pyrazole derivatives from the reaction of chalcones with substituted hydrazine. FT-IR, Mass, and H¹-NMR spectra identified the compounds. The new pyrazoles (Py1-Py4) studies as anti-bacterial against negative and positive gram stain. The prepared compounds gave the high and different abilities to inhibit these bacteria according to the type of the substituted group. The inhibition ratio of pyrazole substituted by the COOH group (Py1) was 28 mm, while pyrazole substituted by OH in the meta position was less able to inhibit.