Synthesis, characterization and study anticancer activity of new Azo –Chalcone with mix Ligand of some divalent metal chelate complexes

Abstract

        In this paper azo-chalcone compound was synthesized by coupling paramino-acetophenone with parabromobenzaldehyde to prepared chalcone , and preparing a mixture of azo-chalcone from reacted diazonium salt of Chalcone with Paracetamol new five complexes of divalent ions (Cu, Zn, Ni, Co, Cd) were prepared by mixture azo-chalcone with 8-hydroxy quinoline, The results show that the mole ratio (metal - ligand) is (1:1:1) for all chelates . The ligand characterized by ¹HNMR, mass spectrum and its complexes were characterized by microanalysis of the elements, UV-Vis, FTIR, molar conduction and magnetic moment azo- chalcone coordinated via (N) atom of azo group and (O) atom of OH group of Paracetamol with metal ions. Based on the obtained results, an octahedral geometry were proposed for all chelate complexes. The effect of the biological examination of Ni (II) complex was tested antitumor Breast cancer cells and compared with healthy cells to show the possibility of using these compounds in a therapeutic manner.