Clinical Evaluation of Some Biochemical and Hematological Variables and Their Relationship to Serum Ferritin Levels of Major Beta Thalassemia Patients in Maysan Governorate - Iraq.

Abstract

Thalassemia is a recessive genetic disease resulting from a disorder and defect in hemoglobin production. The current study was designed to evaluate some hematological and biochemical variables and their relationship to serum ferritin (iron stock ) levels in Thalassemia patients and study them in terms of housing, age and blood types in Maysan Governorate. This study was conducted during the period from December 2020 to the end of October. The results of the current study recorded a highly significant relationship (P<0.000) for all hematological parameters with a decrease in the levels of (HGB) (RBC), (MCV) for patients and an increase in the level of white blood cell count (WBC) and platelet count (PLT) compared to the control. The current study recorded a highly significant relationship (P<0.000) and high levels of all liver enzymes (ALP), (ALT), (AST), (TSB), (TP) compared to the control group. The present study showed a slight decrease in urea levels and an increase in creatine levels compared to the control. The results of linear regression analysis showed a correlation between ferritin and hematological parameters, where the relationship was significant with RBC, HGB, MCV and insignificant with WBC, PLT, while there was a correlation between ferritin levels and liver and kidney enzymes, where the relationship was significant and positive with ALP. (AST) (TSB), and non-significant positive for (ALT), (TP), (Urea), (Creatinine).