Genetic polymorphism of CTLA4 with functional thyroid tests in hypothyroid disease patients

Authors

  • Shahad Tareq Rradeef Dept. of chemistry, Faculty of Education for Girls, , University of Kufa
  • Elham Abed Mahdi Dept. of chemistry, Faculty of Education for Girls, , University of Kufa

DOI:

https://doi.org/10.36329/jkcm/2023/v2.i10.13409

Keywords:

Hashimoto's thyroiditis

Abstract

Objective: To recognize the role of Cytotoxic T-Lymphocyte Antigen 4 CTLA4 gene polymorphism (rs231775A/G) in Hashimoto's thyroiditis (HT) patients and a study its correlation with other clinical data.
Design and Methods
Case-control research was conducted on 200 females, with 100 patients with Hashimoto's thyroiditis aged 18-68 years and 100 age and gender-matched healthy volunteers. Patients were drawn from Al-Sadder Medical City in Al-Najaf Governorate. All participants underwent to medical examinations to ensure they were suffering from Hashimoto's thyroiditis. The Real-time-PCR method was used to analyze the genotyping of the CTLA4 gene, and the levels of T3, T4, TSH, Anti-TPO, and Anti-TG were assessed using an ELISA kit in all study groups

Downloads

Download data is not yet available.

Downloads

Published

2023-11-05

How to Cite

Shahad Tareq Rradeef, & Elham Abed Mahdi. (2023). Genetic polymorphism of CTLA4 with functional thyroid tests in hypothyroid disease patients. Journal of Kufa for Chemical Sciences, 2(10), 17–30. https://doi.org/10.36329/jkcm/2023/v2.i10.13409

Issue

Vol. 2 No. 10 (2023): Journal Of Kufa For Chemical Sciences

Section

Peer-reviewed Articles

License

Copyright (c) 2023 Journal of Kufa for Chemical Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Open-access Statement
The journal « Journal Of Kufa For Chemical Sciences» provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Full-text access to scientific articles of the journal is presented on the official website in the Archives section.

This is in accordance with the BOAI definition of open access. The licensing policy is compatible with the overwhelming majority of open access and archiving policies.

The journal «Journal Of Kufa For Chemical Sciences» is an open access journal, which means all its content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.The journal is licensed by Creative Commons Attribution International( CC Attribution 4.0) .