Estimating the Levels of Some Biomarker in Patients with Chronic Kidney Disease

Abstract

Background: Chronic kidney disease (CKD) constitutes a significant global health of populations concern due to its rising prevalence, elevated morbidity and mortality rates, correlation with diminished quality of life, decreased life expectancy, and substantial financial implications, thereby imposing a considerable burden on healthcare systems. Objective:  The present study aimed to determine some biochemical parameters (glutathione (GSH), urea, uric acid, and creatinine) in individuals suffering  from chronic kidney illness . Materials: The current research was conducted on 90 people, 30 control groups, and 60 patients aged 18-80 with CKD. Samples were collected from Tikrit Central Teaching Hospital in Saladin, Iraq, from September 2023 to December 2023. Results:  The findings demonstrated a significantly lower in GSH levels in CKD patients (4.61 ± 0.2 µmol/L) relative to  control group (9.06 ± 0.09 µmol/L, urea levels in CKD patients (87.35 ± 3.61 mg/dL) had significant  than control group (22.01 ± 0.81 mg/dL, similary for uric acid levels in CKD patients (12.39 ± 0.48 mg/dL) than control group (4.88 ± 0.27 mg/dL, The findings demonstrated a significantly elevated in creatinine levels in CKD patients (2.38 ± 0.07 mg/dL) compared to control group (1.03 ± 0.05 mg/dL) at p<0.05. The results indicate lower levels of glutathione, and higher levels of urea, uric acid, and Creatinine in patients with CKD compared to the healthy group.