Design, Preparation some transition metal complexes of Chalcone-Azo with Paracetamol ligand and Evaluation anti-biological activity of some complexes

Authors

  • Afaq jabber kadhium Department of Chemistry /Faculty of Education for Girls/University of Kufa
  • Mithaq Saeed Mohammed Department of Chemistry /Faculty of Education for Girls/University of Kufa
  • Shownm Hasan Baper Department of Chemistry /Faculty of Education for Girls/University of Kufa

DOI:

https://doi.org/10.36329/jkcm/2023/v3.i1.13523

Keywords:

Chalcone-Azo, Paracetamol compound, Thyroid cancer, antimicrobial activity.

Abstract

This search designed new series complexes of (Mn , Fe, Co, Ni, Cu, and Pd)(II) ,which prepared from Chalcone - Azo derived contained Paracetamol . The results illustrate that, the mole ratio (ligand : metal) (2:1) for all complexes and the geometric shapes of complexes were an Octahedral except Pd(II) complex was Square planer. the complexes characterized by ( UV-Visible, FTIR, C.H.N, Electrical molar conductivity and Magnetic susceptibility). This ligand coordinated with metal ions via (N) atom of Azo group and (O) atom of OH group of Paracetamol , the biological examination tested Pd(II)complex as antitumor Thyroid cancer cells(FTC-133) and compered it with healthy cells to evaluate the possibility of using it as therapeutic method. In addition , it tested Cu(II) and Ni(II) complexes as antimicrobial activity towards two types of Gram negative and Gram positive bacteria

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Published

2023-10-31

How to Cite

Afaq jabber kadhium, Mithaq Saeed Mohammed, & Shownm Hasan Baper. (2023). Design, Preparation some transition metal complexes of Chalcone-Azo with Paracetamol ligand and Evaluation anti-biological activity of some complexes. Journal of Kufa for Chemical Sciences, 3(1), 55–67. https://doi.org/10.36329/jkcm/2023/v3.i1.13523

Issue

Section

Peer-reviewed Articles

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