Synthesis of Modern Amides Thiazolidine Derived From L-Cysteine and Investigation of Their Biological Effects on Cancer Cells

Abstract

      The study included the preparation and characterization of new compounds called thiazolidine-4-carboximaide in three main steps. In the first step, compound (R) was reacted from the reaction of cysteine ​​with different aromatic aldehydes. Then the compound (R)was reacted  with acetic anhydride to prepare the compound (RA). The compound (RA) was reacted with the aromatic amine (phenyl hydrazine) and DCC,HOBT to obtain different amides-4-thiazolidine compounds. All compounds were diagnostic using organic description techniques, FT-IR,magnetic resonance spectroscopy, ¹HNMR, and ¹³CNMR, mass spectroscopy, every the prepared Compounds gave perfect returns. and biological effect prepared compounds:]ML1 ,ML2, ,ML4,ML7 ML8,ML9 [ was studied against cancer cells for two types of cancer lines: human breast cancer line (MCF7) cells, women’s cervical cancer line (Hela), The biological effectiveness of the prepared compoundsML1,ML2, ML4 ML7,ML8 and ML9, was studied against cancer cells for two types of cancer lines, a Michigan cancer foundation (MCF7) and a female cervix carcinoma (Hela). The results of the inspection showed that the compounds ] ML1,ML2, ML4,ML8 ,ML9 [ had high efficacy against a mankind breast cancer cell line and a cell line.  Cervical cancer and compound] ML7[ showed little activity on the two types of cancer cell lines. and calculated Inhibition percentage (% ) of prepared compounds effects a Michigan cancer foundation (MCF7) and a female cervix carcinoma (Hela).