Synthesis and characterization of heterocyclic derivatives from azo-azomethine compounds and evaluation of biological activity

Abstract

This investigation encompasses the synthesis of various heterocyclic derivatives, initiated by the reaction of 5-aminotetrazole with 2-hydroxy-4-methoxybenzaldehyde, resulting in the formation of Azo compound (1). Subsequently, Azo compound (1) undergoes a reaction with 4-methoxyaniline, yielding a Schiff base derivative (2). The derivative (2) is then reacted with various reagents including Glycine, Alanine, Thioglycolic acid, Phthalic anhydride, Malic anhydride, and Succinic anhydride, leading to the production of Imidazolidine (3), Thiazolidine (4), Oxazepine and Oxazepane derivatives (5-7) respectively. These compounds are characterized through Fourier Transform Infrared Spectroscopy (FTIR) ¹HNMR, , and¹³CNMR. Following their synthesis, the biological activity of all synthesized heterocyclic derivatives was evaluated against two distinct bacterial strains.