Body Mass Index effect on Interleukin-2 , its receptor and Liver Functions Tests in Iraqi ovary and uterine Cancers Patients.

Abstract

Interleukin-2 was first identified as a potent T-cell growth factor and Interleukin-2 has a multifaceted role in activating the immune system by interacting with various types of cells. When Interleukin-2 binds to its receptor (Interleukin-2 Receptor), it triggers crucial signaling pathways such as Janus Kinases/Signal Transducer and Activator of Transcription Proteins (JAK/STAT), phosphoinositide-3-kinase/Protein kinase B (PI3K/AKT) and Mitogen-Activated Protein Kinases (MAPKs). This study aimed to the Body Mass Index effect on Interleukin-2 and its receptor in Iraqi patients with ovary and uterine cancers. Methods: Serum IL-2 and IL-2R levels were measured in patients with ovarian cancer (n = 40), uterine cancer (n=40) and controls (n = 40). Results: Serum IL-2 and its receptor, were elevated in patients compared to controls (p < 0.001). Conclusion: The role of IL-2 and IL-2R within the tumor microenvironment remains a fascinating and vital area of exploration. Their multifaceted interplay mediating both immune activation and regulation has profound implications on the immune response to various cancers such as ovarian and uterine cancer.