A bio scientific study of the new gold complex as an anti-breast cancer agent, as well as its preparation , Molar Conductivity and Spectral identification of some other metal complexes

Abstract

Synthesis of Heterocyclic Organic Ligand involved the preparation of non-homogeneous ring ligand derived from ortho-aminobenzylamine. This was achieved by the azo compound prepared in the first step. The second step included the reaction of the azo compound with  4-(benzyloxy)benzaldehyde .ligand was characterized using various spectroscopic and diagnostic techniques, including mass spectrometry, proton nuclear magnetic resonance, Fourier-transform infrared spectroscopy , and ultraviolet-visible spectroscopy . In addition, precise analysis of C, H, N elements and melting point measurements were conducted. the molar ratio (1:2) (M:L) was found for the ligand (BPDIM ) to prepare metal complexes for cobalt, and copper (divalent) while maintaining a molar ratio of (1:1) for gold complexes (trivalent). While supporting the values of accurate analysis of elements (C.H.N) and the results of flame atomic absorption spectroscopy, the proposed molecular formulas for all studied complexes were investigated. In addition, infrared spectroscopy, Electronic spectra of metal complexes, molar conductance.The new complexes showed variations in conductance depending on the metal ion and oxidation state. This study aimed to conduct an in vitro cytotoxicity comparative study of BPDIM  and its Au(III) complex on human breast cancer cells (MCF-7) and other normal cells. The Au(III) complex was found to be highly selective in targeting cancer cells without affecting normal healthy cells, compared to the ligand. Thus, this complex can be considered as a new drug for treating breast cancer cells (MCF-7), and an attempt in the future to study its effect on other types of cancer.