Microwave-Assisted Synthesis of Five and Seven-Membered Heterocycles from Ibuprofen and Study Their Biological Activity
DOI:
https://doi.org/10.36329/jkcm/2024/v3.i3.15885Keywords:
Ibuprofen, imidazolidin-4-oneAbstract
In order to reduce the ulcerogenic effect of ibuprofen carboxylic group has been converted into 7-membered and 5-membered heterocyclic rings. Various 1,3-oxazepane (A3-A6) imidazoldine-2,3-indole (A7-A10) Derivatives of ibuprofen were prepared by cyclization under various reaction conditions in a very good yield. The microbial inhibitory effect of the new agents has been assessed in vitro against Gram-positive and Gram-negative bacteria activity.By creating ibuprofen derivatives, our goal in the current study is to improve the antimycobacterial profile at lower concentrations. The synthesis of derivatives of ibuprofen and their antibacterial and antimycobacterial properties are the subjects of this paper.
Downloads
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Ashwaq Abbas Ali, Nadia Sadiq Majeed
This work is licensed under a Creative Commons Attribution 4.0 International License.
which allows users to copy, create extracts, abstracts, and new works from the Article, alter and revise the Article, and make commercial use of the Article (including reuse and/or resale of the Article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made and the licensor is not represented as endorsing the use made of the work.
How to Cite
