Synthesis, Identification some of new heterocyclic Compounds Derivatives and study of the biological Activity

Abstract

This research includes prepeared of some new heterocyclic compounds from 2-hydroxy napthaldehyde with 2-amino thiazol , 2-amino thiazol  reacted with 2-hydroxy napthaldehyde , to produce shiff base derivative (R),(R) using to synthesis of  some new heterocyclic derivatives  by reactions and reactant with types solvent and materials to synthesis heterocyclic membered ring , first step : Involved synthesis   of  seven heterocyclic  compounds by reacting (R)  with phthalic ,succinic and malic  anhydride respectfully to prepeared oxazepine compounds  (R₁,R₂,R₃) . Second step involves preparing of five- heterocyclic   derivatives  by reacting (R)  with amino acid glycine and thyrocine  in tetra hydro furan to prepare (R₄,R₅).Third step includes preparing of four heterocyclic compounds β-lactam(S₆). All the  compounds were characterized by FT-IR ,H¹NMR,¹³CNMR .Also  compounds were studied the   measurement antibacterial activity.