Correlation of IL10 and IL28B in Iraqi patients infected with HBV infection
DOI:
https://doi.org/10.36329/jkcm/2025/v5.i1.16805Keywords:
HBsAg, IL-10, IL-28BAbstract
Hepatitis B is a liver infection caused by the hepatitis B virus. The infection can be classified as acute (severe and short-term) or chronic (long-term). Hepatitis B can cause chronic infection and promotes people's risk of death from cirrhosis and liver cancer.
The present study aims to detect the levels of IL-10 and IL-28B in hepatitis B virus patients and their biochemical role in early detection of the disease.
During the period from August 2023 to March 2024, blood samples were collected from 153 individuals in the Public Health Laboratory in Najaf and Al-Hakeem General Hospital, aged between (5-70) years, and they were divided into two groups, the control group, which consisted of 40 samples (24 men and 16 women) that were collected from healthy people and the patient group, which consisted of 113 (68 men and 45 women) samples collected from people suspected of being infected with hepatitis B. HBsAg was immunologically detected in all samples using ELISA technology to verify infection with hepatitis B virus. The results have been indicated that the control group (40) were all negative, while in the patient group, 22 of them were negative and 91 were positive. The samples were distributed according to age, gender, and residence, and the results were compared with the control group. It has been found that there were statistically significant differences between the two groups (the patient group and the control group).
The levels of IL-10 and IL-28B in sera were valuated immunologically using ELISA technology in the control and patient groups, and their relationship with HBV infection was determined. The Mean ± SE of IL-10 in the control group was (0.02318 ± 0.00086 ng/L) and the patient group was (0.1465 ± 0.00916 ng/L) with a high significant difference between the two groups (P-value <0.0001). Also, the current study has reported an increase in the level of IL-10 when infected with hepatitis B type, while the level of IL-28B decreases when infected with hepatitis B, the Mean ± SE was (0.1506 ± 0.0089 ng/L) in the patient group and (1.366 ± 0.111 ng/L) in the control group and there was a significant difference between the two groups (P-value <0.0001).
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Copyright (c) 2024 Roa Abdulyemmah Ghanem Rubayii
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