Estimated Advanced Glycation end Products Level and Biochemical parameters for Renal Failure Patients in Kirkuk city

Abstract

Advanced glycation end product (AGE) levels are elevated in patients with decreased renal function, which may contribute to the excess cardiovascular disease in this population. So, the present study assessed the advanced glycation end product level of patients with renal failure. 100 subjects (31 males and 69 females with ages: 15-75 years) reported chronic kidney disease disease who attended Azadi Teaching Hospital, Kirkuk Hospital, and Al-Watan Hospital, Kirkuk, Iraq, from October 2023 to April 2024. The participants in this study were divided into two groups: 100 patients with chronic kidney disease and 40 subjects as control group. The results showed that nearly all of patients were across the age of 60 (39%). Patients had an average body mass index of 18.5-24.9 kg 52%. Eighty-three percent of patients were living in cities. The smoking status of patients was non-smoking 68%. The current outcomes demonstrated a reduction in the concentration of total protein that is significant (P<0.05), albumin, and globulin in patients compared to the control group. On the other hand, the results show a significant (P<0.05) increase in the concentrations of carbonyl and amino group, while a decrease in thiol levels in patients compared to the control group. Otherwise, the results showed that the AGE levels in the serum of patients (3.82±0.016 AU) are significantly higher (P<0.05) than in the control group (3.09±0.028 AU). It is concluded that chronic kidney disease leads to elevated glycation levels and changes in oxidative status.