Synthesis, Characterization and Antibacterial Activity of Schiff-Base Ligand Derived from Naphthaldehyde with its Complexes

Abstract

The formation of a Schiff-Base ligand 2-((2- hydroxynaphthalen-1-yl)methylene)hydrazine/1-carboxamide (L) with  its complexes are set. This ligand has obtained from the condensation of 2-hydroxy-1-naphthaldehyde by semicarbazide. A series of metal complexes were produced by the ligand's interaction with the metal chlorides of Mn(II), Co(II), Ni(II), Cu(II), Zn(II) in addition to Cd(II) . So the analyses showed that the general formula of complexes gave [M(L)Cl]₂ where M= Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II). According to these investigations, the tetrahedral arrangement for Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) was disturbed. Then biological activity for the synthesised compounds was measured and checked against  Bacillus subtilis, Staphylococcus aurius, Escherichia coli and Klebsiella Pneumoniae.  The results were compared with Ampicillin that is used as a main standard antibiotic. Consequently, set of these compounds gave an identical antibacterial activity to the Ampicillin.