Treatment of Liver Cancer by Novel Nano Graft Co-Polymer- Amoxicillin Composite

Abstract

Nano Graft Co-polymer-Drug composite pharmaceutical were created by a two-step reaction process; Step 1: One mole of glycerol and three moles of phthalic anhydride were reacted to create synthesis graft nano co-polymer, which was then characterized using FT-IR, 1H-NMR, AFM, and XRD techniques. Step two: To create a unique nano graft composite drug, this graft nano co-polymer was combined with distinct of medication, Amoxicillin. The resulting drug was then characterized using FT-IR, ¹HNMR, and ¹³C-NMR spectroscopies. Using the software (PyRx and Biovia), the study of molecular docking was conducted to determine the binding position of the ligand of a protein with amino acids. The study examined the effects of the above-prepared composite drug on the HEp-2 liver cancer cell line. The results indicated that compound was highly effective in preventing the spread of hepatic cancer cells, as evidenced by the significant decrease in the percentage of these cells. Additionally, the cytotoxicity of a novel nano graft composite drug with amoxicillin hep-2 cells (IC50=36.932 µg/ml)