Preparation, Characterizations and Biological evaluations of new Nickel Bis (Azo-Salphen) Complex.

Abstract

A new bis azo-salphen ligand (Azo Salicylaldehyde phenylenediamine Schiff base) was synthesized through an initial preparation of the salphen Schiff base via the condensation reaction between salicylaldehyde and o-phenylenediamine, which was subsequently followed by a coupling reaction involving the diazonium salt derived from p-amino acetophenone with the Schiff base component to yield the desired ligand (1,1'-(((1E,1'E)-(((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis(methanylylidene))bis(4-hydroxy-3,1-phenylene))bis(diazene-2,1-diyl))bis(4,1-phenylene))bis(ethan-1-one), this new ligand was characterized with many spectroscopic techniques as ( FTIR, Mass, NMR, Uv-Visible and CHN Elementary analysis ).

   Its nickel complex was prepared and characterized with the previous techniques , certainly, the aforementioned supplementary methodologies, such as molar conductivity and magnetic susceptibility, alongside X-ray diffraction, were employed to ascertain the morphology and to propose its geometric configuration.

The ligand and its nickel complex were biologically examined from three point views: antibacterial zone of inhibition, antioxidant ability and breast cancer MCF7 cell line assay. The results were appointed that the nickel complex more efficient in the inhibition of bacterial and cancer cells, while the azo-salphen ligand has more antioxidant ability than its Nickel Complex.