Synthesis, Characterization and Preliminary Anti-Fungal study of Some New Thio-pyrimidine Derivatives of CIotrimazole

Abstract

The diverse biological activities of chalcone derivatives with N-heterocyclic frameworks are significant in medicinal chemistry. These N-heterocyclic compounds encourage further research and analysis of molecules featuring the α,β-unsaturated carbonyl group along with an N-heterocyclic structure to achieve more targeted biological effects. These compounds exhibit a range of activities, including antibacterial, antifungal, antioxidant, anti-inflammatory, antitubercular, anticancer, antimalarial, and anti-leishmanial properties, found in both natural and synthetic forms. Chalcones have demonstrated various beneficial functions, such as chemo protective and antimicrobial effects, including antifungal activity, as well as antispasmodic effects. The antifungal properties of chalcones have been extensively studied and investigated. In this study, the chemistry and biological activity of the cyclized form of chalcones (Thio-Pyrimidine derivatives) is evaluated using preliminary techniques.