Sulfisoxazole-1,2,3-triazole derivatives synthesis, characterization, and evaluation against breast cancer MCF-7 cell line

Abstract

The current work describes synthesizing, characterizing and evaluating two new 1,4-disubstituted 1,2,3-triazole-linked sulfisoxazole derivatives against a breast cancer MCF-7 cell line. The newly synthesized compounds 1 and 2 were characterized by 1H-NMR, 13C-NMR, and mass spectra. The synthesized compounds were evaluated against the breast cancer MCF-7 cell line. The results show that the synthesized compounds 1 and 2 have weak activity against the breast cancer MCF-7 cell line with IC50 values of 1873.42 µM, and 3750.02 µM, respectively.